Epithelial-Mesenchymal Transition: NF-κB Takes Center Stage

• DOI: 10.4161/cc.3.12.1280
• Publication Date: 2011-01-25T15:17:09Z
• Authors: Margit A. Huber; Hartmut Beug; Thomas Wirth
• Keywords: Mesoderm; 0303 health sciences; 03 medical and health sciences; NF-kappa B; Humans; Cell Differentiation; Epithelial Cells; Models, Biological; 3. Good health

AbstractActivation of the transcription factor NF-?B occurs in many human tumors, and studies have shown that NF-κB can promote cell proliferation oncogenesis, possibly by protecting cells from apoptosis. Little is known, however, about whether involved tumor progression including epithelial-mesenchymal transition (EMT), a central process governing both morphogenesis carcinoma multicellular organisms. In combined vitro/in vivo model mammary carcinogenesis, was essential for induction maintenance EMT metastasis. signaling pathways are its activation should therefore receive attention as potential targets development novel anti-metastatic cancer treatments.