A molecular mechanism of chronological aging in yeast

• DOI: 10.4161/cc.8.8.8287
• Publication Date: 2010-10-25T21:16:35Z
• Authors: Christopher R. Bu...; Christopher J. Mu...; Brian K. Kennedy; Matt Kaeberlein
• Keywords: Life span; Mediator; Model Organism

The molecular mechanisms that cause organismal aging are a topic of intense scrutiny and debate. Dietary restriction extends the life span many organisms, including yeast, efforts underway to understand biochemical genetic pathways regulate this extension in model organisms. Here we describe mechanism by which dietary yeast chronological span, defined as length time stationary cells remain viable quiescent state. We find under standard culture conditions is result cell-extrinsic component linked pH medium. identify acetic acid mediator cell death during aging, demonstrate restriction, growth non-fermentable carbon source, or transferring water increases reducing eliminating extracellular acid. Other extending environmental interventions, such high osmolarity media, deletion SCH9 RAS2, increase cellular resistance conclude induced mortality primary conditions.