Intracellular Ca2+signaling: A novel player in the canonical mTOR-controlled autophagy pathway

• DOI: 10.4161/cib.25429
• Publication Date: 2013-07-29T12:25:30Z
• Authors: Jean-Paul Decuypere; Ram Chandra Paudel; Jan B. Parys; Geert Bultynck
• Keywords: Non canonical

Functional intracellular Ca(2+) signaling is essential for the upregulation of canonical mTOR-controlled autophagy pathway triggered by rapamycin or nutrient deprivation. Moreover, modifications in Ca(2+)-signaling machinery coincide with stimulation. This results enhanced driving process. Yet, mechanisms upstream (the players causing changes signaling) and downstream targets altered signals) this Ca(2+)-dependent remain elusive. Here, we speculate about these based on our current knowledge.