SUMO engages multiple corepressors to regulate chromatin structure and transcription

• DOI: 10.4161/epi.4.7.9807
• Publication Date: 2010-04-30T16:45:18Z
• Authors: Jian Ouyang; Grace Gill
• Keywords: Transcription

AbstractPost-translational modification of many transcription factors and cofactors by the small ubiquitin-related modifier SUMO has been correlated with transcriptional repression. Recent investigations molecular mechanisms underlying SUMO-dependent repression have identified diverse chromatin modifying enzymes associated proteins as effectors changes in structure gene expression. A surprising diversity to be recruited promoters a manner, including histone deacetylase HDAC2, demethylase LSD1, methyltransferase SETDB1, nucleosome remodeling ATPase Mi-2, chromatin-associated HP1 L3MBTL1 -2. These findings suggest that SUMOylation plays central role coordinating modifications important for regulation