New insights into the hygiene hypothesis in allergic diseases

• DOI: 10.4161/gmic.27905
• Publication Date: 2014-01-23T20:55:46Z
• Authors: John Penders; Kerstin Gerhold; Carel Thijs; Kurt Zimmermann; Ulrich Wahn; Susanne Lau; Eckard Hamelmann
• Keywords: Hygiene hypothesis; Atopy; Dysbiosis

There is convincing evidence from both human and animal studies suggesting that the infant intestinal microbiota plays an important role in regulating immune responses associated with development of allergic diseases. To date there are, however, still no definite bacterial taxa or particular subsets have been consistently diseases, which mainly attributable to methodological dissimilarities between studies. As such a need apply different concepts enhance deeper more refined understanding relationship gut allergies. Within our recent we reported colonization by clostridia early infancy increased risk atopic dermatitis. Using subsequent mediation analysis, demonstrated birth mode having older siblings strongly impacted turn affected The results these analyses contributed stronger for causal link order on allergy through modulation composition.