Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome

• DOI: 10.4161/gmic.27923
• Publication Date: 2014-01-27T17:21:50Z
• Authors: Bruno P Chumpitazi; Emily B Hollister; Numan Oezguen; Cynthia M Tsai; Ann R McMeans; Ruth A Luna; Tor C Savidge; James Versalovic; Robert J Shulman
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; 0303 health sciences; Adolescent; Pilot Projects; Abdominal Pain; Diet; 3. Good health; Gastrointestinal Tract; Irritable Bowel Syndrome; Feces; 03 medical and health sciences; 13. Climate action; Fermentation; Humans; Female; Child; Methane; Hydrogen

We sought to determine whether a low fermentable substrate diet (LFSD) decreases abdominal pain frequency in children with irritable bowel syndrome (IBS) and identify potential microbial factors related efficacy. Pain symptoms, stooling characteristics, breath hydrogen methane, whole intestinal transit time, stool microbiome, metabolite composition were collected and/or documented eight IBS at baseline during one week of an LFSD intervention. (P < 0.05), severity pain-related interference activities 0.05) decreased the subjects while on LFSD. Responders vs. non-responders: four (50%) identified as responders (>50% decrease LFSD). There no differences between non-responders respect production, methane or gut time. characterized by increased pre-LFSD abundance bacterial taxa belonging genera Sporobacter Subdoligranulum 0.02) Bacteroides relative non-responders. In parallel, metabolites differed associated microbiome composition. These pilot study results suggest that may be effective decreasing GI symptoms IBS. Microbial such relate