Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma

• DOI: 10.4161/onci.19789
• Publication Date: 2012-04-20T21:26:37Z
• Authors: Mengxian Zhang; Michael Lahn; Peter E. Huber
• Keywords: 0301 basic medicine; 03 medical and health sciences; Author's View; 3. Good health

To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition and angiogenesis.1.