A novel strategy for modulation of MDSC to enhance cancer immunotherapy

• DOI: 10.4161/onci.20201
• Publication Date: 2012-04-20T21:29:16Z
• Authors: Tomar Ghansah
• Keywords: Myeloid-derived Suppressor Cell; Cancer Immunotherapy

Myeloid derived suppressor cells (MDSC) suppress anti-tumor immune responses. Our recent publication provides evidence that SHIP-1 plays a prominent role in pancreatic tumor development by regulating MDSC. Therefore, may be potential therapeutic target for the treatment of MDSC-related hematological malignancies and solid tumors.