The CCL5/CCR5 axis promotes metastasis in basal breast cancer

• DOI: 10.4161/onci.23660
• Publication Date: 2013-04-26T12:52:42Z
• Authors: Marco Velasco-Vel...; Richard G. Pestell
• Keywords: Basal (medicine); CCL5; Breast cancer metastasis

Recently, we have shown that the CCL5/CCR5 axis is active in patients affected by an aggressive basal subtype of breast cancer. Using preclinical models, demonstrated CCR5 promotes cancer invasiveness and metastatic potential, while inhibition abrogates them. Thus, antagonists may constitute alternative therapeutic approach for