Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma

dNaM NKG2D
DOI: 10.4161/onci.26663 Publication Date: 2014-01-21T19:34:48Z
ABSTRACT
Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful implement strategies aimed at increasing the density of NKG2D and DNAM-1 ligands on surface cancer cells, endowing them with capacity activate potent antitumor natural killer-cell responses.
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