Aging increases Oxidative Stress and Renal Expression of Oxidant and Antioxidant Enzymes that Are Associated with an Increased Trend in Systolic Blood Pressure

• DOI: 10.4161/oxim.2.3.8819
• Publication Date: 2010-08-11T15:40:16Z
• Authors: Pedro Gomes; Sónia Simão; Elisabete Silva; Vanda Pinto; João S. Amaral; Joana Afonso; Maria Paula Serrão; Maria João Pinho; Patrício Soares-d...
• Keywords: Male; 0301 basic medicine; Aging; Kidney Cortex; Superoxide Dismutase; 610; NADPH Oxidases; Blood Pressure; NADPH Oxidase; Hydrogen Peroxide; Catalase; Oxidants; Rats, Inbred WKY; Antioxidants; Rats; Oxidative Stress; 03 medical and health sciences; Heart Rate; NADPH Oxidase 4; 616; Animals; Inbred WKY; Lipid Peroxidation

The aim of this study was to investigate whether the effects aging on oxidative stress markers and expression major oxidant antioxidant enzymes associate with impairment renal function increases in blood pressure. To explore this, we determined age-associated changes lipid peroxidation (urinary malondialdehyde), plasma urinary hydrogen peroxide (H(2)O(2)) levels, as well H(2)O(2) production, young (13 weeks) old (52 male Wistar Kyoto (WKY) rats. Urinary levels production by cortex medulla rats were higher than their counterparts. This accompanied overexpression NADPH oxidase components Nox4 p22(phox) Similarly, superoxide dismutase (SOD) isoforms 2 3 catalase increased from Renal parameters (creatinine clearance fractional excretion sodium), diastolic pressure heart rate not affected aging, although slight systolic observed during 52-week period. It is concluded that aged WKY does functional or marked hypothesized lack stress-associated may result defenses counteract damaging H(2)O(2).