Rab5 activation as a tumor cell migration switch

• DOI: 10.4161/sgtp.28195
• Publication Date: 2014-04-01T17:53:32Z
• Authors: Pablo Mendoza; Jorge Díaz; Patricio Silva; Vicente A Torres
• Keywords: Rab; Internalization

Increased cell migration is an acquired feature of metastatic cancer cells and relies on derailed signal transduction pathways. Intracellular vesicular trafficking plays a key role in due to its intricate involvement cargo transport membrane composition. In the last decade, endocytosis has been implicated found be responsible for internalization receptors at plasma membrane, where integrin fine-tuning receptor tyrosine kinase signaling by are major mechanisms. Accumulating evidence suggested link between endosome dynamics, migration, invasion, which small GTPases Rab family have central roles. We recently determined that Rab5 activation crucial event promoting focal adhesion disassembly, concomitant with invasion cells. The mechanisms underlying this novel currently unclear, their elucidation will provide insight into function metastasis.