Coordination of glucose and glutamine utilization by an expanded Myc network
Proto-Oncogene Proteins c-myc
0303 health sciences
03 medical and health sciences
Glucose
Glutamine
Neoplasms
Animals
Humans
Signal Transduction
3. Good health
DOI:
10.4161/trns.1.1.12142
Publication Date:
2010-09-17T15:42:44Z
AUTHORS (3)
ABSTRACT
Glucose and glutamine are the most abundant circulating nutrients and support the growth and proliferation of all cells, in particular rapidly growing and dividing cancer cells. Several recent studies implicate an expanded Myc network in how cells sense and utilize both glucose and glutamine. These studies reveal an unappreciated coordination between glycolysis and glutaminolysis, potentially providing new targets for therapeutic intervention in cancer.
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