Evaluation of mycobacterial virulence using rabbit skin liquefaction model

0301 basic medicine Virulence Colony Count, Microbial Mycobacterium tuberculosis Mycobacterium bovis Mycobacterium 3. Good health Disease Models, Animal 03 medical and health sciences Animals Humans Tuberculosis Rabbits Skin
DOI: 10.4161/viru.1.3.11748 Publication Date: 2010-10-27T14:03:15Z
ABSTRACT
Liquefaction is an important pathological process that can subsequently lead to cavitation where large numbers of bacilli be coughed up which in turn causes spread tuberculosis humans. Current animal models study the liquefaction and evaluate virulence mycobacteria are tedious. In this study, we evaluated a rabbit skin model as rapid for assessment using M. bovis BCG, avirulent strain H37Ra, smegmatis, H37Ra strains complemented with selected genes from virulent H37Rv. We found prime and/or boosting immunization, all these live bacteria at enough high number could induce liquefaction, induced stronger more severe lesions shorter time compared injection. The caused by dose BCG (5×106) were most followed smegmatis being least pathogenic. It interest note none above heat-killed liquefaction. When was certain wild type H37Rv, some produced than H37Ra. These results suggest visual, convenient, useful different mechanisms
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