Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin

• DOI: 10.4162/nrp.2008.2.1.17
• Publication Date: 2009-10-12T11:00:20Z
• Authors: Mi-Young Park; Hoon-Jeong Kwon; Mi-Kyung Sung
• Keywords: 0301 basic medicine; 03 medical and health sciences; Original Research; 3. Good health

Aloin is a physiologically active anthraquinone present in aloe.There are two isomers of aloin, aloin A and B, occurring as mixture diastereomers.The objective this study was to determine the bioavailability tissue distribution aloin.Rats were gavaged with 11.8g/kg levels its conjugates measured plasma, tissues, urine.Plasma level showed peak at 1hr after administration concentration 59.07±10.5 ng/ml.The 24 h cumulated urinary 0.03% initial dose.These results suggest that absorbed reaches plasma within 1-1.5 significant portion possibly metabolized or excreted feces.These can apply determination adequate intake aloe products achieve desired biological effect, interprete vitro results.