Coconut-derived D-xylose affects postprandial glucose and insulin responses in healthy individuals

• DOI: 10.4162/nrp.2011.5.6.533
• Publication Date: 2012-01-09T10:09:29Z
• Authors: Yun Jung Bae; Youn-Kyung Bak; Bumsik Kim; Min-Sun Kim; Jin-Hee Lee; Mi-Kyung Sung
• Keywords: 2. Zero hunger; 03 medical and health sciences; 0302 clinical medicine; Original Research

Metabolic alterations including postprandial hyperglycemia have been implicated in the development of obesity-related diseases.Xylose is a sucrase inhibitor suggested to suppress glucose surge.The objectives this study were assess inhibitory effects two different concentrations xylose on and insulin responses evaluate its efficacy presence other macronutrients.Randomized double-blind cross-over studies conducted examine effect D-xylose response following oral tolerance test (OGTT).In 1, overnight-fasted subjects (n = 49) consumed sucrose solution (50 g 130 ml water) containing 0, 5, or 7.5 powder.In 2, 50) meal 60 muffin 200 sucrose-containing solution).The control provided 64.5 carbohydrates, 4.5 fat, 10 protein.The was identical except 5 added mix.In xylose-containing solutions exhibited significantly lower area under curve (AUCg) (AUCi) values for 0-15 min (P < 0.0001, P 0.0001), 0-30 0-45 0-60 0-90 0.0001) 0-120 0.0071, 0.0016).In AUCg AUCi 0.0005), 0.0002, 0.0025), 0.0396, 0.0246).In conclusion, showed an acute suppressive surges.