The Prevalence and Clinical Features of Non-responsive Gastroesophageal Reflux Disease to Practical Proton Pump Inhibitor Dose in Korea: A Multicenter Study

• DOI: 10.4166/kjg.2016.68.1.16
• Publication Date: 2016-07-26T00:51:25Z
• Authors: Hong Jun Park; Soo-Heon Park; Ki-Nam Shim; Yong Sung Kim; Hyun Jin Kim; Jae Pil Han; Yong Sik Kim; Byoung Wook Bang; Gwang Ha Kim; Gwang Ho Baik; Hyung Hun Kim; Seon Young Park; Sung Soo Kim
• Keywords: Reflux esophagitis; Adult; Male; 0301 basic medicine; Proton pump inhibitors; Gastric acid; R; Proton Pump Inhibitors; Middle Aged; 3. Good health; 03 medical and health sciences; Treatment Outcome; Gastroesophageal reflux; Heartburn; Republic of Korea; Gastroesophageal Reflux; Prevalence; Medicine; Humans; Female; Aged

Background/Aims In Korea, there are no available multicenter data concerning the prevalence of or diagnostic approaches for non-responsive gastroesophageal reflux disease (GERD) which does not respond to practical dose proton pump inhibitor (PPI) in Korea. The purpose this study is evaluate and symptom pattern GERD. Methods A total 12 hospitals who were members a Korean GERD research group joined study. We used composite score (CS) as scale standardized questionnaire based on frequency severity typical symptoms defined "non-responsive GERD" follows: subject with erosive (ERD) whose CS was decreased by at least 50% after standard-dose PPIs 8 weeks non-erosive (NERD) half-dose 4 weeks. Results 234 subjects analyzed. Among them, 87 147 confirmed have ERD NERD, respectively. 26.9% (63/234). rates different between NERD groups (25.3% vs. 27.9%, respectively, p=0.664). There differences responsive sex (p=0.659), age (p=0.134), BMI (p=0.209). However, initial epigastric pain fullness higher (p=0.044, p=0.014, respectively). Conclusions conclusion, showed that rate substantially high up 26%. addition, patients frequently dyspeptic such fullness.