The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

• DOI: 10.4168/aair.2011.3.2.67
• Publication Date: 2011-03-22T05:39:00Z
• Authors: Tao Zheng; Jinho Yu; Min Hee Oh; Zhou Zhu
• Keywords: Pathogenesis; Atopy

Atopic dermatitis (AD) is an inflammatory disease characterized by pruritic skin lesions. The pathogenesis of AD may include disrupted epidermal barrier function, immunodysregulation, and IgE-mediated sensitization to food environmental allergens. also part a process called the atopic march, progression from allergic rhinitis asthma. This has been supported multiple cross-sectional longitudinal studies experimental data. Research on mechanisms centered adaptive immune system with emphasis T-helper 1 (Th1)-Th2 paradigm. Recently, conceptual focus largely shifted primary defect in epithelial as initial event providing significant insight into initiation pointing complex secondary interplay immunological sequelae disruption. Further understanding will help development more effective treatment for ultimately, preventative algorithms march. In this review we highlight recent advances our