Long-term Efficacy of Intravenous Immunoglobulin Therapy for Moderate to Severe Childhood Atopic Dermatitis

• DOI: 10.4168/aair.2011.3.2.89
• Publication Date: 2011-03-22T05:39:38Z
• Authors: Sue-Jung Jee; Joo-Hwa Kim; Hey-Sung Baek; Ha-Baik Lee; Jae-Won Oh
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article; 3. Good health

fects such as renal toxicity.Approximately 20% of patients discontinue cyclosporine treatment within 2 years because adverse effects. 5,6ntravenous immunoglobulin (IVIg) is prepared by cold ethanol fractionation pooled plasma, followed additional viral inactivation procedures.The final product a pure concentrate IgG (with small amounts IgA and IgM) with intact function minimal impurities. 7,8The immunomodulatory mechanism IVIg thought to be mediated interactions the Fc portion receptors complement, antigen-binding variable region F(ab)2, or substances other than antibodies in preparations. 9Previous research has shown that significantly modulates production several cytokines, including interleukin (IL)-1, IL-2, IL-3, IL-4, IL-5, IL-10, tumor necrosis factor-α, granulocyte-macrophage