Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study

• DOI: 10.4168/aair.2015.7.6.573
• Publication Date: 2015-09-03T06:34:54Z
• Authors: Song-I Yang; Byoung-Ju Kim; So-Yeon Lee; Hyo-Bin Kim; Cheol Min Lee; Jinho Yu; Mi-Jin Kang; Ho-Sung Yu; Eun Lee; Young-Ho Jung; Hyung Young Kim; Ju-Hee Seo; Ji-Won Kwon; Dae Jin Song; GwangCheon Jang; Woo-Kyung Kim; Jung Yeon Shim; Soo-Young Lee; Hyeon Jong Yang; Dong In Suh; Seo Ah Hong; Kil-Yong Choi; Youn Ho Shin; Kangmo Ahn; Kyung Won Kim; Eun-Jin Kim; Soo-Jong Hong
• Keywords: Tobacco smoke

Purpose: To investigate whether prenatal exposure to indoor fine particulate matter (PM2.5) and environmental tobacco smoke (ETS) affects susceptibility respiratory tract infections (RTIs) in infancy, compare their effects between postnatal exposure, determine genetic factors modify these effects.Methods: The study population consisted of 307 birth cohort infants.A diagnosis RTIs was based on parental report a physician's diagnosis.Indoor PM2.5 ETS levels were measured during pregnancy infancy.TaqMan used for genotyping nuclear factor erythroid 2-related (Nrf2) (rs6726395), glutathione-S-transferase-pi (GSTP) 1 (rs1695), glutathione-S-transferase-mu (GSTM) 1. Microarrays genome-wide methylation analysis.Results: Prenatal increased the lower (LRTIs) infancy (adjusted odds ratio [aOR]=2.11).In terms combined both ETS, pollutants LRTIs (aOR=6.56);however, this association not found exposure.The Nrf2 GG (aOR=23.69),GSTM1 null (aOR=8.18),and GSTP1 AG or (aOR=7.37)genotypes LRTIs-promoting 2 pollutants.Such upper RTIs.Conclusions: may increase LRTIs.This effect can be modified by polymorphisms reactive oxygen species-related genes.