Usefulness ofIn VivoandIn VitroDiagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin

• DOI: 10.4168/aair.2017.9.4.347
• Publication Date: 2017-05-12T07:34:15Z
• Authors: Semra Demir; Asli Gelincik; Nilgun Akdeniz; Esin Aktas-Cetin; Muge Olgac; Derya Unal; Belkis Ertek; Raif Coskun; Bahattin Colakoğlu; Gunnur Deniz; Suna Buyukozturk
• Keywords: Quinolone; Hypersensitivity reaction

Purpose: Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results.Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) others.We aimed to detect usefulness diagnostic tests reactions quinolones evaluate different including latest GFX.Methods: We studied 54 patients (mean age 42.31±10.39years; 47 female) with 57 due 10 nonatopic tolerable control subjects.A detailed clinical history, skin test (ST), single-blind placebo-controlled drug provocation (SBPCDPT), as well basophil activation (BAT) lymphocyte transformation (LTT) were performed culprit alternative ciprofloxacin (CFX), moxifloxacin (MFX), levofloxacin (LFX), ofloxacin (OFX), GFX.Results: The majority (75.9%) reported immediate type various quinolones.The most common was CFX (52.6%) reaction urticaria (26.3%).A quarter (24.1%) reacted SBPCDPTs, although their STs negative; while false ST positivity 3.5% ST/SBPCDPTs concordance only 1.8%.Both BAT LTT not found useful in hypersensitivity.Cross-reactivity primarily observed LFX OFX (50.0%), whereas it least MFX others, GFX hypersensitive degree other 16.7%.Conclusions: These results suggest that STs, BAT, supportive a prediction cross-reactivity.Drug (DPTs) necessary identify both quinolones.