Relationships Between High-Resolution Computed Tomographic Features and Lung Function Trajectory in Patients With Asthma

• DOI: 10.4168/aair.2023.15.2.174
• Publication Date: 2023-04-05T01:38:07Z
• Authors: Joo-Hee Kim; Kyung Eun Shin; Hun Soo Chang; Jong-Uk Lee; Seung-lee Park; Jai Soung Park; Jong Sook Park; Choon-Sik Park
• Keywords: Air trapping; High-resolution computed tomography; Expiration; Guideline

A subset of asthmatics suffers from persistent airflow limitation, known as remodeled asthma, despite optimal treatment. Typical quantitative scoring methods to evaluate structural changes airway remodeling on high-resolution computed tomography (HRCT) are time-consuming and laborious. Thus, easier simpler required in clinical practice. We evaluated the usefulness a simple, semi-quantitative method based 8 HRCT parameters by comparing with decline post-bronchodilator (BD)-FEV1 those BD-FEV1 that normalized over time relationships BD-FEV1.Asthmatics (n = 59) were grouped into 5 trajectories (Trs) according 1 year. After 9-12 months guideline-based treatment, including emphysema, bronchiectasis, anthracofibrosis, bronchial wall thickening (BWT), fibrotic bands, mosaic attenuation inspiration, air-trapping expiration, centrilobular nodules classified present (1) or absent (0) 6 zones.The Tr5 group 11) was older exhibited BD-FEV1. The Tr4 groups 12), who had lower baseline time, longer durations frequent exacerbations, higher doses steroid use compared Tr1-3 36), normal emphysema BWT scores than (P 8.25E-04 P 0.044, respectively). Scores for other not significantly different among Tr groups. inversely correlated multivariate analysis 1.70E-04, 0.006, respectively).Emphysema associated asthmatics. Our system may be an easy-to-use estimating limitation.