New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study

• DOI: 10.4168/aair.2023.15.6.795
• Publication Date: 2023-11-10T00:01:15Z
• Authors: Mengru Zhang; Alyn H. Morice; Fengli Si; Li Zhang; Qiang Chen; Shengyuan Wang; Yiqing Zhu; Xianghuai Xu; Li Yu; Zhongmin Qiu
• Keywords: Chronic Cough; Refractory (planetary science); Guideline

Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) unexplained (UCC). These led to initiation this study, which reported demographic characteristics, manifestations, long-term outcomes on a large series consecutive RCC/UCC patients, providing guideline-led real-world clinical experience.Retrospective baseline information was obtained from Clinical Research Database (January 2016 May 2021). At least 6 months after last clinic visit, included subjects were prospectively followed up.Three hundred sixty-nine RCC UCC patients (199 females, 53.9%) analyzed. The median duration 24.0 (12.0-72.0) months. Laryngeal symptoms in 95.9% patients. common triggers for coughing talking (74.9%), pungent odors (47.3%), eating (45.5%), cold air (42.8%). considered 38.2%, remainder 228 had UCC, with an equal sex distribution (P = 0.66). Among 141 RCCs, 90.8% (128) reflux cough, more responsive current treatments < 0.01). Although most test results between similar, commonly inappropriately treated Nineteen (7.7-41.1) final 31.2% still coughed persistently, while 68.8% improvement or remission. favorable treatment (including improvement, control, spontaneous remission) than Coughs long before initial visit 0.01), frequent urinary incontinence being sensitive "talking" 0.01) "cold air" less likely be solved.The only improve two-thirds indicators failure those air."