Fractional exhaled nitric oxide in Korean children with allergic rhinitis

• DOI: 10.4168/aard.2015.3.6.439
• Publication Date: 2015-12-08T17:15:50Z
• Authors: Seung Hyun Moon; Hae Ji Jang; Yoon Sung Park; Woo Yeon Lee; Dae Hyun Lim; Jeong Hee Kim
• Keywords: Methacholine; Exhalation

Purpose: Fractional exhaled nitric oxide (FeNO) is useful for the diagnosis of allergic rhinitis (AR) as well bronchial asthma (BA). However, FeNO may differ according to race, age, and other determinants. There have been few studies about in Korean children with AR. The aims this study were evaluate value AR compare FeNO, determinants levels between AR, BA, combined BA. Methods: This included 647 aged 5 17. classified into groups after performing skin test, measurement, pulmonary function methacholine challenge test: those nonallergic (NAR), healthy controls,. Results: values FEV1 (forced expiratory volume one second) %predicted 94.4%± 12.6%, 93.8%± 20.7%, 90.0%± 17.4% respectively. (32.3± 25.0 ppb), BA (31.1± 20.5 (34.5± 30.4 ppb) significantly higher compared NAR (16.8± 13.5 controls (15.9± 12.5 ppb). was no significant difference among patients ≥ 4 positive results (36.6± 29.2 than < test (27.6± 20.7 When receiver operating characteristic curve analysis prediction showed 0.756 area under curve, cutoff level 16 ppb. Conclusion: In study, had increased FeNO. It suggested that eosinophilic inflammation without BHR or clinical asthma. (Allergy Asthma Respir Dis 2015;3:439-445)