A randomized controlled trial to compare the efficacy of regenerated and non-regenerated oxidized cellulose gauze for the secondary treatment of local bleeding in patients undergoing hepatic resection

• DOI: 10.4174/astr.2021.100.4.193
• Publication Date: 2021-04-02T02:11:00Z
• Authors: Chengshuo Zhang; Dazhi Fu; Fengshan Wang; Xinping Zhong; Lei Yang; Gang Wu; Baifeng Li; Jialin Zhang
• Keywords: Clinical endpoint

Oxidized cellulose is available in many forms, but manufactured using either a regenerated or non-regenerated process. In this study, we evaluated the effects of 2 different hemostatic agents for treatment local bleeding patients undergoing hepatic resection.This was monocentric, parallel-group, randomized, and controlled clinical trial to compare oxidized gauze (ORCG) with (ONRCG) hepatectomy. The primary endpoint time hemostasis at target site. secondary endpoints were postoperative drainage volume on first days after surgery hospital stay.There no significant difference between ORCG ONRCG groups from column analysis (238.8 ± 121.6 seconds vs. 193.7 85.3 seconds, P = 0.068), there differences rates success 120 (18.4% 24.3%; odds ratio [OR], 0.703; 95% confidence interval [CI], 0.231-2.136) 300 (71.1% 89.2%; OR, 0.298; CI, 0.085-1.041). However, group superior according survival (log-rank test, 0.044). Moreover, also (P 0.436, 0.381) stay 0.537, 0.200).ONRCG not inferior as agent liver resection.