Sustained effects of intralymphatic pollen-specific immunotherapy on Japanese cedar pollinosis

• DOI: 10.4193/rhin19.301
• Publication Date: 2020-02-24T10:11:38Z
• Authors: T. Terada; S. Omura; Y. Kikuoka; M. Suzuki; Y. Inaka; T. Inui; M. Matsuda; T. Nabe; R. Kawata
• Keywords: Nasal provocation test

Background: Intralymphatic immunotherapy (ILIT) for allergic patients requires only a few intralymphatic injections of the allergen.However, effectiveness and safety Japanese cedar pollinosis are unclear.The objectives this study were to clarify whether how long ILIT is effective pollinosis, its safety. Methods:In an open pilot investigation followed by double-blind, placebo-controlled study, with received 3 inguinal pollen extracts before first season.The symptom medication score (SMS), nasal provocation testing scoring visual analogue scale (VAS) assessed after first-third seasons. Results:(1) Although mild adverse events induced at injected site, severe not noted.( 2) During latter part season, ILIT-treated (n=12) tended show improved SMS compared placebo-treated (n=6) without statistical significance.When VAS was significant.(3) The effects continued until second or third season.(4) Neither allergen-specific antibodies nor Treg/Breg cells changed in peripheral blood.