Comparative clinical and airway inflammatory features of asthmatics with or without polyps

• DOI: 10.4193/rhino09.095
• Publication Date: 2021-05-20T10:55:42Z
• Authors: Lara Bilodeau; Marie-Eve Boulay; Philippe Prince; Pierre Boisvert; Louis-Philippe Bo...
• Keywords: Adult; Male; Adolescent; Eosinophil Cationic Protein; Drug Resistance; Sputum; Respiratory Mucosa; Middle Aged; Severity of Illness Index; Asthma; Fibronectins; 3. Good health; Airway Obstruction; Eosinophils; 03 medical and health sciences; Nasal Polyps; 0302 clinical medicine; Spirometry; Disease Progression; Humans; Female; Anti-Asthmatic Agents; Skin Tests

BACKGROUND: Nasal polyposis (NP) is associated with a more severe and steroid-resistant asthma. OBJECTIVE: To compare clinical and airway inflammatory features of asthmatics with or without NP. METHODS: Two groups of asthmatic patients were studied: group 1; n=39, with NP; group 2; n=40, without NP. Asthma control was assessed according to the Asthma Control Scoring System (ACSS). Expiratory flows, induced sputum, and blood eosinophils were also measured. RESULTS: ACSS score was lower (poorer control) in group 1 (meanA+-SEM = 73A+-3%) compared with group 2 (82A+-2%, p=0.01). FEV1 (mean of predicted value A+- SEM) was 81A+-3 for group 1 and 96A+-3 for group 2 (p=0.001), and the FEV1/FVC ratio was lower in group 1 (70A+-2%) compared with group 2 (76A+-1%, p=0.01). Blood and induced sputum eosinophils, as well as fibronectin and eosinophil cationic protein levels, were higher in group 1. CONCLUSION: Asthmatic subjects with NP have increased airway obstruction, increased inflammatory cells and reduced asthma control compared to those without NP. This may suggest a contribution of nasal polyps to the severity of asthma or a common susceptibility to develop upper and lower airways mucosal inflammation.