Memory Improvement by Yokukansankachimpihange and Atractylenolide III in the Olfactory Bulbectomized Mice

• DOI: 10.4236/aad.2016.52003
• Publication Date: 2016-06-06T07:44:17Z
• Authors: Hisanao Izumi; Yuzuru Sasaki; Yasushi Yabuki; Yasuharu Shinoda; Nina Fujita; Satoshi Yomoda; Kohji Fukunaga
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Alzheimer's Disease (AD) shows cognitive dysfunction as core symptoms and Behavioral Psychological Symptoms of Dementia (BPSD). Since acetylcholine nerve system derived from septum is collapsed in the AD patients, we have used Olfactory Bulbectomized (OBX) mice whose cholinergic largely impaired septum. Recently, Yokukansankachimpihange (YKH), a traditional Japanese Kampo medicine has for BPSD addition to improve patients. However essential components cognition improvement their mechanism are unknown. In present study, found that Atractylenolide III (Aen-III), one YKH, improved deficits depression OBX mice. were orally administered with Aen-III (1.0 3.0 mg/kg) YKH extracts daily 18 days. Like extracts, treatments ameliorated depression-like behavior observed Importantly, administration significantly restored decreases Ca2+/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation phosphorylation IV (CaMKIV) cyclic AMP response element binding (CREB). The restoration CaMKII CaMKIV signaling closely related increased BDNF levels. Furthermore, ATP reduction was rescued by (3.0 (1000 treatment. summary, component ameliorates dysfunctions via restoring signaling.