<i>In vitro</i> differentiation of human umbilical cord-derived mesenchymal stem cells into CD34<sup>+</sup> cells via CD34 antibody

• DOI: 10.4236/jbise.2013.68a1005
• Publication Date: 2013-08-20T08:13:07Z
• Authors: Shengnan Guo; Libin Guo; Maoxiang Sun; Wenyue Ma; Yujia Lu; Ying Liu
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

CD34+cells differentiated from mesenchymal stem cells (MSCs) have a strong biological function in cardiovascular regeneration. However, the molecular mechanisms of and methods to improve CD34+ cell differentiation MSCs, especially human MSCs (hUC-MSCs) are still unclear. In current study, effect CD34 antibody on umbilical cord (UC)-derived is determined. The results demonstrated that expression cd34 protein significantly increased hUC-MSCs treated with antibody. addition, proliferation after treatment Moreover, PI3K, AKT, p-AKT proteins, which signaling molecules related differentiation, by suggest could promote into PI3K/AKT may be involved this important process.