Delivery Outcome in Women with Major Sickle Cell Syndrome: A Comparative Study of the Homozygous Forms “SS” versus the Heterozygous “SC”

• DOI: 10.4236/ojog.2015.512100
• Publication Date: 2015-10-27T22:51:41Z
• Authors: Amah Biova Adama-...; Abdoul-Samadou Ab...; Kossi Edem Logbo-...; Kodjo Fiagnon; Akila Bassowa; Koffi Akpadza
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Objectives: To determine the prevalence of women who delivered in the two major sickle cell syndromes, “SS” and “SC”, and to identify maternal and early neonatal prognosis inherent to each form. Material and Methods: This is a comparative, descriptive and retrospective cross-sectional study of 226 files of women carrying major sickle cell syndrome (66 cases of “SS” form versus 160 cases of “SC” form), collected from May 2008 to May 2013 at the Gynecology and Obstetrics Clinic of the Sylvanus Olympio’s University Hospital of Lome. Data were processed by Epi Info 6 software. For comparison of variables, the Chi-2 test of Fisher with significance as p major sickle cell syndromes represent 0.8% of all the deliveries during the study period. Caesarean section, especially prophylactic one, was the dominant mode of delivery. The SS forms have been exposed to have more vaso-occlusive crises (22.7% vs. 13.1%; p = 0.04, OR = 0.31), more blood transfusion (57.6% vs. 29.4%; p = 7 × 10-5, OR = 3.2) and more puerperal infections (p gave exposure to greater maternal morbidity. Resuscitative measures in adults and newborns should be reinforced at the delivery time of these “at-risk-pregnancies”.