Antidiabetic Drugs in Combination with Hydroxychloroquine Improve Glycemic Control in Alloxan Induced Diabetic Rats

• DOI: 10.4236/pp.2014.57082
• Publication Date: 2014-06-26T04:22:17Z
• Authors: Shaheda Zannah; Md. Saiful Islam; A. F. M. Towheedu...; Md. Asaduzzaman; Abdul Alim Al Bari; Yusuf Ali; Gazi Jahirul Islam; A. H. M. Khurshid...; Hazrat Ali; Mamunur Rashid
• Keywords: Hydroxychloroquine; Alloxan

Worldwide prevalence of diabetes mellitus has become an issue great concern in current decades. This life threatening disease is associated with worsening glycemic control and progressive metabolic dysfunctions. Objective: Current study aimed to investigate the effect hydroxychloroquine (HCQ) as adjunct glibenclamide or metformin on alloxan induced diabetic rats. Methods: HCQ was combined separately two conventional anti-diabetic drugs; metformin. At first, (120 mg/kg) rats were treated single dose (850 mg/70 kg BW), (10 BW) (300 intraperitoneally once daily for weeks. Then non fixed combinations (5 (150 (425 injected along those three drugs alone four Results: In rats, glibenclamide, their combination therapies reduced blood glucose level significantly but are most effective. Glibenclamide also (P