Protective effect of Ginkgo flavonoids, amifostine, and leuprorelin against platinum-induced ovarian impairment in rats

• DOI: 10.4238/2014.july.24.6
• Publication Date: 2014-07-28T07:23:49Z
• Authors: Z. Chang; H.L. Wang; H. Du
• Keywords: Amifostine; Leuprorelin; Intraperitoneal injection

Platinum-induced ovarian impairment is a consequence of treatment for malignant tumors.We compared the protective effects Ginkgo flavonoids, amifostine, and leuprorelin on in rats.Fifty rats were randomly divided into A, B, C, D, E groups, which given saline, cisplatin, cisplatin plus leuprorelin, respectively.Ovarian weight was significantly greater groups C D with group B (83.5 ± 6.7 86.8 10 vs 56.8 5.4 mg).The total follicle numbers higher than (60.5 3.9, 63.8 5.1, 67.7 3.5 49.6 4.5), apoptotic index reduced (35.7 2.0, 37.4 1.6, 30.5 2.9 65.3 2.9%).The ovaries had protein mRNA expression levels cytoplasmic Cytochrome c (Cyt-c) protease activating factor-1 (Apf-1) to A; Cyt-c five-fold higher.The Apf-1 lower B. Administration or amifostine protected against induced by ©FUNPEC-RP www.funpecrp.com.br