Embolus-carried vascular endothelial cell growth factor 165 improves angiogenesis in thromboangiitis obliterans

• DOI: 10.4238/2014.march.17.2
• Publication Date: 2014-03-21T09:44:52Z
• Authors: Q. Liu; H.C. Zhou; X.L. Yang; Y.P. Zhao; H.P. Luo; C.W. He; X.B. Wan
• Keywords: Embolus; Microvessel

We investigated neovasculization effects of emboluscarried human vascular endothelial cell growth factor 165 (VEGF )encoded adenovirus (Ad) vector in the hindlimbs rats with thromboangiitis obliterans (TAO).Rats were equally divided into blank control (I), TAO model (II), embolus (III), Ad-VEGF intravascular treatment (IV), intramuscular (V), and (VI) groups.After interventional treatment, effect test gene was observed using immunohistochemistry.At 1 week after administration, compared group II, groups V VI had significantly increased microvessel densities, but no significant difference between VI.At 2 weeks, exhibited densities.At both showed a ratio α-smooth muscle actin count fiber count, whereas them.At also differences these ©FUNPEC-RP www.funpecrp.com.br