Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk

• DOI: 10.4238/2014.may.16.7
• Publication Date: 2014-05-16T19:35:43Z
• Authors: W.K. Zhou; L.Y. Huang; L. Hui; Z.W. Wang; B.Z. Jin; X.L. Zhao; X.Z. Zhang; J.X. Wang; J.C. Wang; R.Z. Wang
• Keywords: Adult; Male; Glioma; Middle Aged; Polymorphism, Single Nucleotide; 3. Good health; DNA-Binding Proteins; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; Alleles; Genetic Association Studies; Aged

We aimed to investigate the role of 4 single nucleotide polymorphisms xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, roles gene-gene interactions risk developing this type cancer.We collected samples from 225 glioma cases 262 controls genotyped rs3136038, rs2276466 using a 384-well plate format with Sequenom MassARRAY platform.Individuals carrying rs1800067 GG genotype were more likely have an increased when compared carriers A/A co-dominant model, odds ratio (OR) [95% confidence interval (CI)] 2.85 (1.14-7.76).However, we did not find association for ©FUNPEC-RP www.funpecrp.com.