Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis

• DOI: 10.4238/2015.august.14.21
• Publication Date: 2015-08-17T07:31:41Z
• Authors: F.C.G. Evangelista; D.R.A. Rios; D.D. Ribeiro; M.G. Carvalho; L.M.S. Dusse; A.P. Fernandes; A.P. Sabino
• Keywords: Factor VII

Recent studies have shown an association between thrombosis and factor VII (FVII), tissue (TF), angiotensinconverting enzyme (ACE).This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, ACE-287 insertion/ deletion (I/D) polymorphisms present increased risk of venous thrombosis, heart disease, ischemic stroke compared controls.In this study, we investigated the frequencies these their arterial thrombosis.For G/A polymorphism, there were 57.3% heterozygote (HT) genotypes 8.3% homozygote (HM) in patients, 45.2% HT 15.4% HM controls.For ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 14 (3): 9585-9594 (2015) G/T 37.5% 3.1% 32.7% 4.8% controls.The polymorphism A/G was not found any samples analyzed.For I/D 43 (40.6%)HT 63 (59.4%)HM controls 28 (45.2%)HT 34 (54.8%)HM patients.No significant difference observed by comparing patients no presence evaluated occurrence thrombotic events.