Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer
Male
0301 basic medicine
Carcinogenesis
Kaplan-Meier Estimate
Middle Aged
Prognosis
3. Good health
Gene Expression Regulation, Neoplastic
Pancreatic Neoplasms
MicroRNAs
03 medical and health sciences
0302 clinical medicine
13. Climate action
Lymphatic Metastasis
Biomarkers, Tumor
Disease Progression
Humans
Female
Neoplasm Invasiveness
Aged
Neoplasm Staging
DOI:
10.4238/2015.december.23.2
Publication Date:
2016-01-04T05:20:35Z
AUTHORS (5)
ABSTRACT
MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the associations between miR-494 expression and clinicopathological features. The survival correlations were analyzed by using the Kaplan-Meier method and Cox proportional hazards model. The level of miR-494 expression was significantly downregulated in pancreatic cancer tissues (mean relative expression level ± SD, 0.48 ± 0.11) as compared to matched adjacent normal tissues (1.80 ± 0.28, P < 0.05). We found significant correlations between the miR-494 expression levels and TNM stage (P = 0.009), lymphatic invasion (P = 0.036), vascular invasion (P = 0.011), distant metastasis (P = 0.007), and tumor grade (P = 0.031). Pancreatic cancer patients with a low miR-494 expression level had a shorter overall survival than those with a high miR-494 expression level (P < 0.05). Reduced miR-494 expression in pancreatic cancer tissues is correlated with tumor progression and might be an independent, poor prognostic factor for patients with pancreatic cancer.
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