Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment

• DOI: 10.4238/2015.may.22.10
• Publication Date: 2015-05-25T11:29:31Z
• Authors: M. Luo; X.H. Zhou; T. Zou; K. Keyim; L.M. Dong
• Keywords: DIO2; SNP

We investigated type II deiodinase (DIO 2 ) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) a Uygur population.We studied the DIO Thr92Ala (rs225014) ORFa-Gly3Asp (rs12885300) of 129 unrelated MCI cases 131 matched controls.All were genotyped using SNaPshot SNP genotyping assays.Serum measured by radioimmunoassay.Levels triiodothyronine thyroxine group significantly lower than those control group.Genotype allele frequencies gene between groups not different.There was no association genotype genders both groups.ORFa-Gly3Asp different patients controls gender.The Asp less frequent among male compared to (odds ratio = 0.471, 95% confidence interval 0.261-0.848).However, female carriers more 2.842, 1.326-6.09).Serum ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 14 (2): 5407-5416 (2015) individuals Ala/Ala Thr/Thr or Thr/Ala genotype.Serum Gly/Gly Gly/Asp Asp/Asp carriers.Decreased may influence incidence population.DIO play role patients.