Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations

• DOI: 10.4238/2015.october.21.18
• Publication Date: 2015-10-27T08:49:21Z
• Authors: L. Xu; J. Lei; Q.Z. Wang; J. Li; L. Wu
• Keywords: Concomitant; Large cell

Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics genotype-specific subsets patients with NSCLC help ensure optimal identification whose tumors harbor these two driver mutations. incidence ALK investigated 763 specimens by immunohistochemistry using a D5F3 antibody, EGFR were assessed amplification refractory mutation system (ARMS) 222 adenocarcinoma. Of these, 73 (9.6%) detected as being ALK-positive; designation young age, female gender, never-smokers, lymph node metastasis, poor tumor differentiation, but not histology. identified 102 (45.9%) adenocarcinoma samples, more frequent females never-smokers. No difference age observed. Specifically, we several cases complex mutations, concomitant rearrangements. These results suggest that women never-smokers are at risk for rearrangement. We also study.