Prevalence of human papillomavirus (HPV) type 16 variants and rare HPV types in the central Amazon region

• DOI: 10.4238/vol10-1gmr992
• Publication Date: 2011-02-08T11:02:16Z
• Authors: M.M. Castro; I.P. Farias; C.M. Borborema-Sa...; G. Correia; S. Astolfi-Filho
• Keywords: Human papillomavirus 16; 0303 health sciences; 03 medical and health sciences; DNA, Viral; Humans; Uterine Cervical Neoplasms; Capsid Proteins; Female; Sequence Analysis, DNA; Polymerase Chain Reaction; Brazil; 3. Good health

Infection by human papillomavirus (HPV) is one of the primary causes mortality cancer in northern Brazil.Sexually active women from Manaus, Amazonas, without cytological alterations and with pre-malignant malignant were examined for HPV virus, identified via PCR sequencing.The target region this study was part L1 capsid gene HPV.Twentythree samples that PCR-positive sequenced.Analysis 336 bp demonstrated a high incidence high-risk types population as HPVs 16, 33, 58, 66, 68.HPV type 16 most prevalent, presenting two variants similar to Asian-American (AA) East-Asian (As) variants.A rare 13 related "Heck's disease" also detected.This preliminary provides important information about circulating Amazonas State.