Experiment study of total anthraquinone in Cassiae Semen on lipid peroxidation and PPAR-γ expression in liver tissues of rats with alcoholic fatty liver

• DOI: 10.4268/cjcmm20111225
• Publication Date: 2011-07-13T13:08:30Z
• Authors: LUO Xianqin
• Keywords: Oil Red O

To investigate the effect of total anthraquinone in Cassiae Semen on lipid peroxidation and peroxisome proliferator activated receptors gamma (PPAR-gamma) expression liver tissues rats with alcoholic fatty liver.Referring to literature, it was established animal models feeding alcohol. Rats were randomized into 6 groups, except normal group, other 5 groups had been administered alcohol two times a day for 3 months. killed at end this experiment. It respectively measured that contents ALT, AST, AKP, TG, TC, HDL-C, LDL-C, MDA, SOD, FFA serum HL, LPL, liver. The left leaf observed by histopathological staining, immunohistochemical staining RT-PCR used observe effects expressions PPAR-gamma mRNA.Compared model could remarkably decrease content MDA increase SOD experimental induced alcohol; Total group similar but lighten inflammatory cell intiltration fibrosis increasing. results showed that: compared group,the mRNA (P < 0.01). Compared 0.01).The has good treatment hepatic fat diet rats. possible action mechanism possess obvious regulating disorder metabolism, ameliorating function, as well anti-lipidperoxidation, increasing cells