Killing Effect of Gamma Irradiation on Angiostrongylus cantonensis in Snails

• DOI: 10.4269/ajtmh.1993.48.827
• Publication Date: 2017-05-10T17:52:11Z
• Authors: Hsiu-Hua Pai; Ying-Chin Ko; Eng-Rin Chen
• Keywords: Gamma Irradiation

Cobalt-60 gamma irradiation was used to kill the larvae of Angiostrongylus cantonensis in four groups snails that were irradiated at a rate 15.4 Gy/min for 16.23 min (0.25 kGy), 32.47 (0.50 48.70 (0.75 and 64.94 (1.00 respectively. Third-stage (infected stage) isolated from these 50 administered each experimental animal via an esophageal tube. At dosage 0.25 kGy, mean ± SD number worms recovered 30 rats mice 15.6 6.5 11.3 6.2, These significantly different nonirradiated (control) groups, which 28.9 9.6 (P < 0.05) 16.6 10.3 Worms cellular infiltrations lung tissue histopathologically identified 0.25-kGy-irradiated group as well control group. eosinophilic meningitis also noted brain groups. No or pathologic findings observed heart, lung, infected with exceeding 0.50 kGy. It is therefore concluded kGy sufficient prevent successful infection rats.