Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease

• DOI: 10.4269/ajtmh.20-0122
• Publication Date: 2020-05-19T07:01:46Z
• Authors: Martha Valéria Ta...; Renata Junqueira ...; Gabriel Cordeiro ...; Fabio Paiva Siqueira; Clerio Francisco ...; Marcelo Teixeira ...; Fernanda de Souza...; Luiz Henrique Con...; Mauro Felippe Fel...; Andréa Silvestre ...
• Keywords: Myocardial fibrosis; Chagas Disease; Endomyocardial fibrosis

Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients sudden cardiac death through ventricular arrhythmia. The associations of fibrosis detected by magnetic resonance (CMR) parameters non-sustained tachycardia (NSVT) were evaluated. This cross-sectional study included in early stages (n = 47) and a control group 15). Patients underwent evaluation, including CMR examination. Myocardial assessment measurement late gadolinium enhancement (LGE), native T1, extracellular volume (ECV) was performed. There an increase arrhythmias among different disease, combined decrease the left ejection fraction (LVEF) also right systolic function S' wave on tissue Doppler. Fibrosis mass ECV associated Rassi score, extrasystole, E/e' ratio logistic regression model adjusted for age gender. maintained association presence NSVT, even after adjustments LVEF assessed CMR. receiver-operating characteristic area under curve global (0.85; 95% CI: 0.71-0.99) NSVT greater than that (0.75; 0.54-0.96), although this difference not statistically significant. Extracellular could be marker increased risk arrhythmia presenting independent initial chronic cardiomyopathy, adjustment LVEF.