Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia

• DOI: 10.4269/ajtmh.23-0873
• Publication Date: 2024-07-09T13:37:23Z
• Authors: Ayzsa Tannis; Suzanne Newton; Angelica Rico; Maritza Gonzalez; Monica Benavides; Jessica N. Ricaldi; Helena Rodriguez; Laura D. Zambrano; Marcela Daza; Shana Godfred-Cato; Jennifer D. Thomas; Jacqueline Acosta; Panagiotis Maniatis; Jonathan B. Daniels; Veronica Burkel; Elizabeth C. Ailes; Diana Valencia; Suzanne M. Gilboa; Denise J. Jamieson; Marcela Mercado; Julie M. Villanueva; Margaret A. Honein; Martha L. Ospina; Van T. Tong
• Keywords: Adult; Male; Adolescent; Zika Virus Infection; Infant, Newborn; Pregnancy Outcome; Infant; Zika Virus; Colombia; Dengue; Young Adult; 0302 clinical medicine; Pregnancy; Humans; Female; Prospective Studies; Pregnancy Complications, Infectious

ABSTRACT. Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Niños was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women (n = 1,519) during February 2017–September 2018 and their infants (n = 1,080) during June 2017–March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3–7.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7–2.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.