Oral Immunotherapy with Cow's Milk Allergy: Five Years' Experience from a Single Center in Turkey

• DOI: 10.4274/balkanmedj.galenos.2020.2020.1.140
• Publication Date: 2020-07-10T10:48:46Z
• Authors: Esen Demir; Nursen Ciğerci Gü...; Figen Gülen; Remziye Tanaç
• Keywords: Cow's milk allergy; Oral immunotherapy; Milk allergy; Cow milk; Center (category theory); Single Center

Background Oral immunotherapy for cow’s milk allergy is an effective treatment option because of its ability to increase the threshold clinical reactions. Aims To present our experience oral in pediatric outpatient clinic, and evaluate long-term efficacy risk factors adverse reactions during immunotherapy. Study design Single-center retrospective cohort study. Methods Forty-two patients with Immunoglobulin-E-mediated who complied protocol were evaluated this The consisted a rapid escalation phase food challenge step that included doses. During build-up phase, increasing quantities administered until patient was able consume 200 mL daily. Results mean age starting 40.2±3.2 (range, 36-156) months, 54.8% (n=23) males. duration 18.1±5.6 9-41) weeks, maintenance 29.1±11.6 12-63) months. immunotherapy, 36 (78% mild 22% moderate) occurred 16 (38%) patients. There no differences (p=0.19), milk-specific Immunoglobulin-E levels (p=0.17), cumulative provocative doses challenges (p=0.78) between two groups without wheal diameters higher group (p=0.03). difference onset history anaphylaxis (p=0.38). had more (p=0.04) number (p=0.01), up-dosing compared anaphylaxis. Conclusion high efficacy. Adverse occur about 40% cases are mostly mild. It should be caution diameter skin prick test.