Serum Zonulin Levels in Patients with Hashimoto’s Thyroiditis

• DOI: 10.4274/bmj.galenos.2022.2022.6-15
• Publication Date: 2022-12-26T10:27:45Z
• Authors: Zehra Sucuoğlu İş...; Sedat Yıldırım; Erdal Gündoğan; Hakan Sarı; Suat Hayri Küçük; Ahmet Engin Atay
• Keywords: Intestinal Permeability

Objective: Hashimoto's thyroiditis, also known as chronic lymphocytic is the most common autoimmune thyroid disease in children and adolescents.The exact mechanism that triggers autoimmunity thyroiditis not fully known.Many pathologies, including disruption of intestinal epithelial barrier causes production an inappropriate immune response by interaction submucosal cells with antigens, have been accused.Zonulin a protein modulates permeability tight junctions between mucosal cells.Abnormal up-regulation Zonulin increased central to development diseases.Methods: A total 53 adult patients newly diagnosed 70 previously receiving hormone replacement therapy 62 healthy controls were enrolled study.Patients other or systemic disorders excluded.Hemogram parameters, biochemical variables serum zonulin levels participants examined.Results: There was no significant elevation patient group currently compared control group.Zonulin levels, which important place modulation, can be affected environmental factors, so they should carefully evaluated.A statistically correlation observed anti-thyroid peroxidase (anti-TPO) antibody groups included our study.There age, body mass index cholesterol values. Conclusion:A anti-TPO indicator autoimmunity, suggests this molecule plays role pathogenesis thyroiditis.The results study supported larger-scale studies longer follow-up periods.