Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

• DOI: 10.4274/jcrpe.galenos.2018.2018.0206
• Publication Date: 2019-05-28T13:33:45Z
• Authors: Erdal Eren; Ayça Törel Ergür; Şükriye Pınar İşg...; Eda Çelebi Bitkin; Merih Berberoğlu; Zeynep Şıklar; Firdevs Baş; Servet Yel; Serpil Baş; Elif Söbü; Abdullah Bereket; Serap Turan; Halil Sağlam; Zeynep Atay; Oya Ercan; Tülay Güran; Mehmet Emre Atabek; Hüseyin Anıl Korkmaz; Aylin Kılınç Uğurlu; Ayşehan Akıncı; Esra Döğer; Enver Şimşek; Emine Demet Akbaş; Ayhan Abacı; Ülkü Gül; Sezer Acar; Eda Mengen Uçaktürk; Melek Yıldız; Edip Ünal; Ömer Tarım
• Keywords: Galactorrhea; Cabergoline; Prolactinoma; Etiology

We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases pediatric hyperprolactinemia in a large multicenter study.We reviewed records 233 hyperprolactinemic patients, under 18 years age, who were followed by different centers. The patients divided as having microadenomas, macroadenomas, drug-induced idiopathic hyperprolactinemia. Complaints their mode treatment (medication and/or surgery) outcomes evaluated detail.The mean age with was 14.5 years, 88.4% females. In terms etiology, microadenomas observed 32.6%, macroadenomas 27%, 22.7% 6.4%. Other causes defined 11.3%. Common complaints females (n=206) sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea weight gain, whereas headache, gynecomastia, short stature blurred vision common males (n=27). Median prolactin levels 93.15 ng/mL, 241.8 74.5 93.2 69 ng/mL for hyperprolactinemia, other respectively. Of 172 77.3% treated cabergoline 13.4% bromocriptine. 20.1% pituitary adenomas underwent surgery.We present largest cohort children adolescents literature date. Hyperprolactinemia is more highly effective practical use adolescents, due its biweekly dosing. Indications surgery need be revised.