Serum IGF-1 and IGFBP-3 Levels in Healthy Children Between 0 and 6 Years of Age - Original Article

• DOI: 10.4274/jcrpe.v3i2.17
• Publication Date: 2011-06-08T11:49:23Z
• Authors: Bilgin Yüksel; M. Nuri Özbek; Neslihan Önenli M...; Feyza Darendeliler; Bahar Budan; Aysun Bideci; Ergün Çetinkaya; Merih Berberoğlu; Olcay Evliyaoğlu; Ediz Yeşilkaya; İlknur Arslanoğlu; Şükran Darcan; Ruveyde Bundak; Oya Ercan
• Keywords: growth hormone deficiency; Male; 0301 basic medicine; Turkey; 03 medical and health sciences; Sex Factors; Reference Values; Humans; Insulin-Like Growth Factor I; Child; Human Growth Hormone; Age Factors; Infant, Newborn; Infant; IGFBP-3; Fetal Blood; Childhood; 3. Good health; Insulin-Like Growth Factor Binding Protein 3; Child, Preschool; IGF-1; Growth hormone deficiency; Original Article; Female

Along with growth hormone (GH) levels, measurements of serum insulin-like factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) are used in the diagnosis GH deficiency monitoring efficacy safety long-term treatment. The purpose present study was to establish reference values for IGF-1 IGFBP-3 healthy Turkish children less than 6 years age.This designed as a multicenter project. Five hundred sixty-seven younger age from different geographical regions Turkey, weight height between 10th 90th percentiles according national standards were included study. In addition anthropometric parameters, levels measured all subjects.Although not statistically significant, infants at months lower those 3 months. showed slow increase age. Serum girls compared boys only No correlation found either body mass index (BMI) or standard deviation scores (SDS). A weak observed concentrations.The age- gender-specific reported this will aid receiving