Thyroid Functions in Long-Term Survivors of Pediatric Hodgkin’s Lymphoma Treated with Chemotherapy and Radiotherapy - Original Article

• DOI: 10.4274/jcrpe.v3i2.18
• Publication Date: 2011-06-08T11:49:23Z
• Authors: Metin Demirkaya; Betül Sevinir Hal...; Lütfi Özkan; Okan Akacı
• Keywords: Subclinical infection

Post-treatment endocrine disturbances are common in cancer patients who have received radiotherapy or chemotherapy. The objective of this study was to evaluate the thyroid functions long-term survivors pediatric Hodgkin's lymphoma treated with chemotherapy and radiotherapy.Thyroid 55 (M/F:2.05/1) complete remission were evaluated retrospectively.The mean age at diagnosis 10.35±4.09 (range: 2.83-17) years follow-up period 5.54±3.68 0.92-13.92) years. All chemotherapy; a total 50 (90.9%) underwent radiotherapy, 42 (76.4%) whom neck/mantle radiotherapy. Thyroid function tests abnormal 14 (24.5%) normal - remaining 41 (74.5%). A subclinical overt hypothyroidism made 11 (78.6%) 3 (21.4%) tests, respectively. Nearly one-fourth all disorders detected first year follow-up. statistically significant correlation found between dose mantle disorder (p=0.002). In addition, correlations established examination ultrasonography findings (p <0.001 p=0.006, respectively).Radiation-induced may develop starting as early after treatment dose-dependent. Patients, particularly those been exposed neck, must be followed up closely for occurrence dysfunctions.