Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis

• DOI: 10.4274/tnd.2021.70962
• Publication Date: 2021-11-12T08:51:27Z
• Authors: Alp Sarıteke; İrem Fatma Uludağ; Berk Özyılmaz; Yaşar Zorlu; Ufuk Şener; Figen Tokuçoğlu
• Keywords: Hippocampal sclerosis; BETA (programming language); Association (psychology)

Objective:We aimed to determine the association between a polymorphism in promoter region of IL-1beta gene resulting enhanced transcription and clinical phenotype temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Materials Methods:The frequency single nucleotide (SNP) that results C>T transition 511 base pairs are five prime start site group 21 patients TLE+HS, without (TLE-HS), 23 healthy volunteers. Results:The -511T allele was 11/21 TLE-HS group, 13/21 TLE+HS 12/23 control group.Chi-square analysis genotype distribution showed no significant difference TLE-HS, group. Conclusion:There -511/C>T SNP variation TLE+HS.