Acute Stroke Management in Türkiye: Intravenous Tissue Plasminogen Activator and Thrombectomy NöroTek: Türkiye Neurology Single Day Study

• DOI: 10.4274/tnd.2023.70292
• Publication Date: 2023-10-06T13:27:36Z
• Authors: Mehmet Akif Topçu...; Atilla Özcan Özdemir; Ethem Murat Arsava; Aygül Güneş; Özlem Aykaç; Elif Sarıönder Ge...; Murat Çabalar; Vildan Yayla; Hacı Ali Erdoğan; Mücahid Erdoğan; Zeynep Özdemir Acar; Semih Giray; Yüksel Kablan; Zeynep Tanrıverdi; Ülgen Yalaz Tekan; Talip Asil; Çetin Kürşad Akpınar; Vedat Ali Yürekli; Bilgehan Acar; Hadiye Şirin; Ayşe Güler; Recep Baydemir; Merve Akçakoyunlu; Levent Öcek; Mustafa Çetiner; Bijen Nazlıel; Hale Batur Çağlayan; Nedim Ongun; Alper Eren; Zülfikar Arlıer; Utku Cenikli; Mustafa Gökçe; Songül Bavli; Erdem Yaka; Ayça Özkul; Bahar Değirmenci; Ufuk Aluçlu; Canan Togay Işıkay; Eda Aslanbaba; Mine Sorgun; Emrah Aytaç; Halil Ay; Refik Kunt; Songül Şenadım; Yaprak Özüm Ünsal; Neslihan Eşkut; Zekeriya Alioğlu; Arda Yılmaz; Hamit Genç; Ayşe Yılmaz; Aysel Milanoğlu; Erdem Gürkaş; Eylem Değirmenci; Hesna Bektaş; İrem İlgezdi; Adnan Burak Bilgiç; Şenol Akyol; Levent Güngör; Nilüfer Kale; Eda Çoban; Nilüfer Yeşilot; Esme Ekizoğlu; Özgü Kizek; Oğuzhan Kurşun; Özlem Kayım Yıldız; Aslı Bolayır; Aysın Kısabay; Birgül Baştan; Zeynep Acar; Buket Niflioğlu; Bülent Güven; Dilaver Kaya; Nazire Afşar; Duran Yazıcı; Eren Toplutaş; Esra Özkan; Faik İlik; Fatma Birsen İnce; Gülseren Büyükşer...; Halil Önder; Hasan Hüseyin Kar...; Hasan Hüseyin Kozak; Hayri Demirbaş; İpek Midi; İsa Aydın; M. Tuncay Epçeliden; Murat Mert Atmaca; Mustafa Bakar; Mustafa Şen; Nilda Turgut; Onur Keskin; Özlem Akdoğan; Ufuk Emre; Özlem Bilgili; Pınar Bekdik Şiri...; Recep Yevgi; Sinem Yazıcı Akkaş; Tahir Yoldaş; Taşkın Duman; Tuğba Özel; Ali Ünal; Babür Dora; Tuğrul Atasoy; Bilge Piri Çınar; Tülin Demir; Turgay Demir; Ufuk Can; Yıldız Aslan; Demet Funda Baş; Ufuk Şener; Zahide Yılmaz; Zehra Bozdoğan; Gökhan Özdemir; Yakup Krespi; Şerefnur Öztürk
• Keywords: Metrik; acute stroke; metric; treatment window; R; Trombolitik Tedavi; Tedavi Penceresi; Prognosis; Trombektomi; Treatment Window; Akut İnme; Prognoz; thrombectomy; Acute Stroke; Acute stroke; Medicine; Thrombolytic Therapy; prognosis; Neurology. Diseases of the nervous system; Metric; RC346-429; Thrombectomy; thrombolytic therapy

Objective: To reveal the profile and practice in patients with acute stroke who received intravenous tissue plasminogen activator (IV tPA) and/or neuro-interventional therapy in Türkiye. Materials and Methods: On World Stroke Awareness Day, May 10, 2018, 1,790 patients hospitalized in 87 neurology units spread over 30 health regions were evaluated retrospectively and prospectively. Results: Intravenous tPA was administered to 12% of 859 cases of acute ischemic stroke in 45 units participating in the study. In the same period, 8.3% of the cases received neurointerventional treatment. The rate of good prognosis [modified Rankin score (mRS) 0–2] at discharge was 46% in 83 patients who received only IV tPA [age: 67 +- 12 years; National Institutes of Health Stroke Scale (NIHSS): 12 +- 6; hospital stay, 24 +- 29 days]; 35% in 51 patients who underwent thrombectomy (MT) alone (age: 64 +- 13 years; NIHSS: 14.1 +- 6.5; length of hospital stay, 33 +- 31 days), 19% in those who received combined treatment (age: 66 +- 14 years; NIHSS: 15.6 +- 5.4; length of hospital stay, 26 +- 35 days), and 56% of 695 patients who did not receive treatment for revascularization (age: 70 +- 13 years; NIHSS: 7.6 +- 7.2; length of hospital stay, 21 +- 28 days). The symptom-to-door time was 87 +- 53 minutes in the IV treatment group and 200 +- 26 minutes in the neurointerventional group. The average door-to-needle time was 66 +- 49 minutes in the IV tPA group. In the neurothrombectomy group, the door-to-groin time was 103 +- 90 minutes, and the TICI 2b-3 rate was 70.3%. In 103 patients who received IV tPA, the discharge mRS 0–2 was 41%, while the rate of mRS 0–1 was 28%. In 71 patients who underwent neurothrombectomy, the mRS 0–2 was 31% and mRS 0–1 was 18%. The door-to-groin time was approximately 30 minutes longer if IV tPA was received (125 +- 107 and 95 +- 83 minutes, respectively). Symptomatic bleeding rates were 4.8% in IV recipients, 17.6% among those who received only MT, and 15% in combined therapy. Globally, the hemorrhage rate was 6.8% in patients receiving IV tPA and 16.9% in MT. Conclusion: IV thrombolytic and neurointerventional treatment applications in acute ischemic stroke in Türkiye can provide the anticipated results. Heterogeneity has begun to be reduced in our country with the dissemination of the system indicated by the 'Directive on Health Services to be Provided to Patients with Acute Stroke.'